COVID-19 infection and longevity: an observational and mendelian randomization study.

ABSTRACT:

Background

Studies have indicated that COVID-19 infection may accelerate the aging process in organisms. However, it remains unknown whether contracting COVID-19 affects life expectancy. Furthermore, the underlying biological mechanisms behind these findings are still unclear.

Methods

We conducted a prospective cohort study on 56,504 participants of European ancestry from the UK Biobank who reported the time and number of COVID-19 infection between January 2020 and September 2023. The parental average longevity was used as a proxy for their own longevity. Linear regression was used to assess the relationship between COVID-19 infection and longevity. Furthermore, we investigated the shared genetic basis between COVID-19 and longevity using large-scale genome-wide association

SUBMITTER: Qiu S 

PROVIDER: S-EPMC11887240 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature