CYP2D6 polymorphisms and endoxifen concentration in Chinese patients with breast cancer.

ABSTRACT:

Background

The plasma concentration of endoxifen, the active metabolite of tamoxifen, might be affected by different CYP2D6 genotypes in patients with breast cancer, but solid evidence is still lacking in Asian patients. This prospective study aimed to investigate the relationship between CYP2D6 genetic polymorphisms and endoxifen plasma concentrations among Chinese patients with breast cancer treated with tamoxifen.

Methods

From August 2015 to June 2018, 110 patients with breast cancer were enrolled. CYP2D6 variant alleles and endoxifen plasma concentration were determined using Sanger sequencing and high-performance liquid chromatography-tandem mass spectrometry, respectively.

Results

The most frequent allele of CYP2D6 was *10 (56.4%). The most frequent genotype of

SUBMITTER: Xue C 

PROVIDER: S-EPMC11887348 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature