Atomically-precise Au₂₂(Lys-Cys-Lys)₁₆ nanoclusters for radiation sensitization.

ABSTRACT: Radiotherapy is a leading method for cancer treatment, effectively eliminating cancer cells but often causing collateral damage to surrounding healthy tissue. Radiosensitizers aim to enhance the therapeutic effects of radiotherapy while minimizing harm to normal cells. We recently reported atomically-precise gold nanoclusters, Au₂₂(Lys-Cys-Lys)₁₆, synthesized via a photochemical method coupled with a novel accelerated size-focusing procedure. These nanoclusters exhibit a distinct luminescence emission profile, reflecting exceptional optical purity and the absence of contamination from other nanocluster species. They demonstrate efficient oxygen radicals generation under light irradiation. In this study, we comprehensively evaluated the radiosensitization potential of

SUBMITTER: Zeinizade E 

PROVIDER: S-EPMC11887354 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature