Mapping fatigue: discovering brain regions and genes linked to fatigue susceptibility.

ABSTRACT:

Background

The relationship between the brain and fatigue is gaining increasing attention, with numerous studies indicating that certain specific brain regions may be closely linked to fatigue. Our study aimed to identify brain regions exhibiting significant causal relationships to fatigue and discover potential neurotherapeutic targets associated with fatigue, in the pursuit of seeking new approaches for fatigue treatment.

Methods

A bidirectional two-sample Mendelian randomization (TSMR) method was employed to investigate causal relationships between cortical and subcortical gray matter volumes in 83 regions and fatigue. Then, we utilized frontal cortex expression Quantitative Trait Loci data, employing the methods of Summary-data-based Mendelian Randomization (SMR) and Bay

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11887381 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature