Magnetic resonance diffusion-derived vessel density (DDVD) as a valuable tissue perfusion biomarker for isocitrate dehydrogenase genotyping in diffuse gliomas.

ABSTRACT:

Background

Determining isocitrate dehydrogenase (IDH) mutation is crucial for glioma clinical management. MR diffusion-derived 'vessel density' (DDVD) offers non-invasive tissue perfusion evaluation within the tumor microenvironment. The study attempts to distinguish IDH genotypes of diffuse gliomas using DDVD in whole tumor parenchyma and its habitats.

Methods

This study enrolled 63 patients with diffuse gliomas (30 IDH-mutant and 33 IDH-wildtype) who underwent diffusion-weighted (DW) imaging at 3T. DDVD_b0b10 was the signal difference between the b = 0 and b = 10 s/mm² DW images. DDVD_{b0b10_b10b20} is DDVD_b0b10 minus DDVD_b10b20. nDDVD was DDVD divided by signal intensity at b = 0 s/mm² DW image. Correlations be

SUBMITTER: Ni CX 

PROVIDER: S-EPMC11887403 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature