Safety of Anticoagulation When Undergoing Endoscopic Variceal Ligation: A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

The safety of continuing anticoagulation therapy during endoscopic variceal ligation (EVL) remains controversial. We performed a systematic review and meta-analysis to evaluate the safety of anticoagulation therapy in EVL.

Methods

We systematically searched four electronic databases from their inception until 1 June 2024, for studies that evaluated anticoagulation use and risk of rebleeding among patients undergoing EVL. The primary endpoint was rebleeding after EVL. The secondary endpoints were post-banding ulcer bleeding (PBUB) and variceal eradication rate. The PROSPERO registration number is CRD42024556094.

Results

A total of 5617 participants from nine studies (eight cohort studies and one randomised trial) were included. The most common type of anti

SUBMITTER: Loo JH 

PROVIDER: S-EPMC11887417 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature