Thoracic Electric Impedance Tomography Detects Lung Volume Changes in Amyotrophic Lateral Sclerosis.

ABSTRACT:

Introduction/aims

Spirometry is the conventional means to measure lung function in amyotrophic lateral sclerosis (ALS), but is dependent on patient effort and bulbar strength. We aimed to use electric impedance tomography (EIT), an emerging non-invasive imaging modality, to measure dynamic lung volume changes.

Methods

Twenty-one patients with ALS underwent sitting and supine spirometry for forced vital capacity (FVC), and sitting and supine EIT. There were 13 patients in the high FVC group (FVC ≥ 80% predicted) and 8 in the low FVC group (FVC < 80% predicted). Additional demographic and clinical data were collected from clinical records.

Results

Only the low FVC group had significant loss of lung volumes in the supine position (R ² = 0.89 and p < 0.001). Th

SUBMITTER: Hansen G 

PROVIDER: S-EPMC11887520 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature