Clinicopathological Features of Mixed Connective Tissue Disease-Related Myositis: A Case Series.

ABSTRACT:

Introduction

Mixed connective tissue disease (MCTD) patients often have myositis, however, myopathological and clinical data for MCTD are limited. Recent reports have shown that the pathology of MCTD myositis resembles that of immune-mediated necrotizing myopathy (IMNM), whereas earlier reports described perifascicular atrophy or inflammatory infiltrates predominantly in the perivascular region in MCTD myositis. We aim to describe the clinical and myopathological features of MCTD myositis.

Methods

We analyzed the clinical and myopathological findings of nine myositis patients with U1-RNP antibodies who fulfilled the diagnostic criteria for MCTD.

Results

Eight patients had muscle weakness in the proximal extremities, and overall, six patients had atypical weakness in t

SUBMITTER: Sakamoto N 

PROVIDER: S-EPMC11887522 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature