Induced Pseudomembrane Enrichment in Long Nerve Allograft Reconstruction.

ABSTRACT:

Introduction/aims

Long nerve defects are typically reconstructed with autograft or processed acellular nerve allograft (PNA). PNA is convenient and avoids donor morbidity but lacks the neurotrophic environment of autograft. Increased levels of neurotrophic factors have been identified in pseudomembranes induced around silicone implanted between nerve ends. This study aimed to determine if pseudomembrane can be reliably induced around silicone implanted between nerve ends, and if this enhances regeneration of PNA inset within using a staged technique.

Methods

Lewis rats (n = 24) underwent resection of a 15-mm sciatic nerve. The defect was filled with a silicone tube (n = 12) (MA) or the nerve ends were secured to a muscle bed (n = 12) (NMA). After 4 weeks, the silicone was re

SUBMITTER: Protzuk OA 

PROVIDER: S-EPMC11887527 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature