Identifying Daytime Hypercapnia Using Transcutaneous Carbon Dioxide Monitoring in Patients With Amyotrophic Lateral Sclerosis.

ABSTRACT:

Introduction/aims

Respiratory failure from hypoventilation is the most common cause of death in amyotrophic lateral sclerosis (ALS). However, ALS care rarely assesses hypercapnia, a physiologic measure of hypoventilation. We investigated the prevalence and clinical significance of daytime hypercapnia measured by transcutaneous carbon dioxide (tcCO₂) monitoring in patients with ALS.

Methods

This retrospective study included patients seen at two ALS clinics in the United States between 2012 and 2024 who had tcCO₂ measured concurrently with pulmonary function tests (PFTs), which included forced vital capacity (FVC) and, at one site, maximum inspiratory pressure (MIP). We assessed the prevalence of hypercapnia (tcCO₂ > 45 mmHg), the sensitivity a

SUBMITTER: Morrison AH 

PROVIDER: S-EPMC11887530 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature