Time-Dependent Changes in the Coronary Circulation Triggered by CTO Revascularization: Insights From Intracoronary Physiology.

ABSTRACT:

Background

Physiological changes in the coronary circulation associated with percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) remain largely unknown. This systematic review and meta-analysis aimed to investigate physiological changes in the CTO and donor vessel before and immediately after PCI, as well as at follow-up.

Methods

A comprehensive search of PubMed/MEDLINE and Embase identified relevant studies. The primary end point was the mean difference (MD) between fractional flow reserve myocardium (FFR_myo) of the primary donor vessel before and after CTO revascularization. Secondary outcomes included the difference in FFR_myo, FFR collateral (FFR_coll), FFR coronary (FFR_cor), absolute coronary blood flow,

SUBMITTER: Lombardi M 

PROVIDER: S-EPMC11887561 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature