Gut microbiota alteration was related to subclinical hypothyroidism and dyslipidemia in mice.

ABSTRACT: Gut microbiota has a close connection to different thyroid disorders, yet research on its links to subclinical hypothyroidism (SCH) remains limited and insufficient. In this study, we explored the potential relationship between the gut microbiota and SCH, as well as dyslipidemia in SCH mice. The SCH mouse model was induced using methimazole. The composition of the gut microbiota from mice was then analyzed through 16S rRNA gene sequencing technology. An antibiotic disruption experiment was used to assess how gut microbiota imbalance impacts thyroid function. The SCH mouse models were constructed and accompanied by significant dyslipidemia. The results revealed no significant differences in the Firmicutes to Bacteroidota ratio or α-diversity in gut microbiota from SCH and control mice, and

SUBMITTER: Wang R 

PROVIDER: S-EPMC11887603 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature