Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression.

ABSTRACT:

Background

Depression alleviation following treatment with repetitive transcranial magnetic stimulation (rTMS) tends to be more effective when TMS is targeted to cortical areas with high (negative) resting state functional connectivity (rsFC) with the subgenual anterior cingulate cortex (sgACC). However, the relationship between sgACC-cortex rsFC and the TMS-evoked response in the sgACC is still being explored and has not yet been established in depressed patients.

Objectives

In this study, we investigated the relationship between sgACC-cortical (site of stimulation) rsFC and induced evoked responses in the sgACC in healthy controls and depressed patients.

Methods

For each participant (N = 115, 34 depressed patients), a peak rsFC cortical 'hotspot' for the sgACC and c

SUBMITTER: Duprat RJ 

PROVIDER: S-EPMC11887861 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature