Photoreceptor Outer Segment Reflectivity With Ultrahigh-Resolution Visible-Light Optical Coherence Tomography in Systemic Hydroxychloroquine Use.

ABSTRACT:

Purpose

To evaluate outer retinal organization in normal subjects and those using hydroxychloroquine (HCQ) with ultrahigh-resolution visible-light optical coherence tomography (VIS-OCT).

Methods

Forty eyes of 22 adult subjects were recruited from a tertiary-care retina practice, including controls (20 eyes, 12 subjects, 40 ± 22 years old) and subjects with a history of HCQ use (20 eyes, 10 subjects, 62 ± 17 years old). Each subject was imaged using a custom-built VIS-OCT device (axial resolution 1.3 µm) and U.S. Food and Drug Administration-approved OCT devices.

Results

With the use of VIS-OCT, control subjects demonstrated five and six hyperreflective bands in the foveal and parafoveal regions, respectively, between the outer nuclear layer and Bruch's membrane. These

SUBMITTER: Garg AK 

PROVIDER: S-EPMC11887931 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature