Morphological Comparison of Astrocytes in the Lamina Cribrosa and Glial Lamina.

ABSTRACT:

Purpose

Although the mechanisms underlying glaucomatous neurodegeneration are not yet well understood, cellular and small animal models suggest that lamina cribrosa (LC) astrocytes undergo early morphologic and functional changes, indicating their role as early responders to glaucomatous stress. These models, however, lack the LC found in larger animals and humans, leaving the in situ morphology of LC astrocytes and their role in glaucoma initiation underexplored. In this work, we aimed to characterize the morphology of LC astrocytes in situ and determine differences and similarities with astrocytes in the mouse glial lamina (GL), the analogous structure in a prominent glaucoma model.

Methods

Astrocytes in the LCs of 22 eyes from goats, sheep, and pigs were stochastically la

SUBMITTER: Waxman S 

PROVIDER: S-EPMC11887932 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature