Identification of Immune-Related Genes as Potential Biomarkers in Early Septic Shock.

ABSTRACT:

Introduction

Septic shock, a severe manifestation of infection-induced systemic immune response, poses a critical threat resulting in life-threatening multi-organ failure. Early diagnosis and intervention are imperative due to the potential for irreversible organ damage. However, specific and sensitive detection tools for the diagnosis of septic shock are still lacking.

Methods

Gene expression files of early septic shock were obtained from the Gene Expression Omnibus (GEO) database. CIBERSORT analysis was used to evaluate immune cell infiltration. Genes related to immunity and disease progression were identified using weighted gene co-expression network analysis (WGCNA), followed by enrichment analysis. CytoHubba was then employed to identify hub genes, and their relationshi

SUBMITTER: Liu B 

PROVIDER: S-EPMC11887992 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature