Patient-Selection of a Clinical Trial Primary Outcome: The ENHANCE-AF Outcomes Survey.

ABSTRACT:

Introduction

Before the initiation of the ENHANCE-AF clinical trial, which tested a novel digital shared decision-making tool to guide the use of anticoagulants in stroke prevention for patients with atrial fibrillation, this study aimed to identify the most appropriate, patient-selected primary outcome and to examine whether outcome selection varied by demographic and clinical characteristics.

Methods

Our cross-sectional survey asked 100 participants with atrial fibrillation to rank two alternative scales based on the scales' ability to reflect their experiences with decision-making for anticoagulation. The Decisional Conflict Scale (DCS), a 16-item scale, measures perceptions of uncertainty in choosing options. The 5-item Decision Regret Scale (DRS) focuses on remorse afte

SUBMITTER: Stafford RS 

PROVIDER: S-EPMC11888126 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature