Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns.

ABSTRACT: Even without detailed instruction from the brain, spinal locomotor circuitry generates coordinated behavior characterized by left-right alternation, segment-to-segment propagation, and variable-speed control. While existing models have emphasized the contributions of cellular- and network-level properties, the core mechanisms underlying rhythmogenesis remain incompletely understood. Further, neither family of models has fully accounted for recent experimental results in zebrafish and other organisms pointing to the importance of cell-type-specific intersegmental connectivity patterns and recruitment of speed-selective subpopulations of interneurons. Informed by these experimental findings and others, we developed a hierarchy of increasingly detailed models of the locomotor network. We find

SUBMITTER: Wandler FD 

PROVIDER: S-EPMC11888175 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature