Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia.

ABSTRACT: Macroautophagy (autophagy hereafter) captures intracellular components and delivers them to lysosomes for degradation and recycling¹. In adult mice, autophagy sustains metabolism to prevent wasting by cachexia and to survive fasting, and also suppresses inflammation, liver steatosis, neurodegeneration, and lethality^2,3. Defects in autophagy contribute to metabolic, inflammatory and degenerative diseases, however, the specific mechanisms involved were unclear ⁴. Here we profiled metabolism and inflammation in adult mice with conditional, whole-body deficiency in an essential autophagy gene and found that autophagy deficiency altered fuel usage, and reduced ambulatory activity, energy expenditure, and food intake, and elevated circulating GDF15, CXCL10, and C

SUBMITTER: Ibrahim M 

PROVIDER: S-EPMC11888218 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature