Multi-omic subtypes of Alzheimer's dementia are differentially associated with psychological traits.

ABSTRACT:

Importance

Psychological traits reflecting neuroticism, depressive symptoms, loneliness, and purpose in life are risk factors of AD dementia; however, the underlying biologic mechanisms of these associations remain largely unknown.

Objective

To examine whether one or more multi-omic brain molecular subtypes of AD is associated with neuroticism, depressive symptoms, loneliness, and/or purpose in life.

Design

Two cohort-based studies; Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP), both ongoing longitudinal clinical pathological studies that began enrollment in 1994 and 1997.

Setting

Older priests, nuns, and brothers from across the U.S. (ROS) and older adults from across the greater Chicago metropolitan area (MAP).

Participants

822 d

SUBMITTER: Zammit AR 

PROVIDER: S-EPMC11888240 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature