Targeted genome mining with GATOR-GC maps the evolutionary landscape of biosynthetic diversity.

ABSTRACT: Gene clusters, groups of physically adjacent genes that work collectively, are pivotal to bacterial fitness and valuable in biotechnology and medicine. While various genome mining tools can identify and characterize gene clusters, they often overlook their evolutionary diversity, a crucial factor in revealing novel cluster functions and applications. To address this gap, we developed GATOR-GC, a targeted genome mining tool that enables comprehensive and flexible exploration of gene clusters in a single execution. We show that GATOR-GC identified a diversity of over 4 million gene clusters similar to experimentally validated biosynthetic gene clusters (BGCs) that other tools fail to detect. To highlight the utility of GATOR-GC, we identified previously uncharacterized co-occurring conserved

SUBMITTER: Cediel-Becerra JDD 

PROVIDER: S-EPMC11888242 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature