<i>Candida albicans</i> Colonization Modulates Murine Ethanol Consumption and Behavioral Responses Through Elevation of Serum Prostaglandin E₂ and Impact on the Striatal Dopamine System.

ABSTRACT: Candida albicans is a commensal yeast that is a common component of the gastrointestinal (GI) microbiome of humans. C. albicans has been shown to bloom in the GI tract of individuals with alcohol use disorder (AUD) and can promote and increase the severity of alcoholic liver disease (ALD). However, the effects of C. albicans blooms on the host in the context of AUD or AUD-related phenotypes, such as ethanol preference, have been unstudied. In this work, we report a reduction in ethanol consumption and preference in mice colonized with C. albicans. C. albicans-colonized mice exhibited elevated levels of serum PGE₂ and reduced ethanol preference was reversed by injection with antagonists of PGE₂ receptors. Further, injection of mice wi

SUBMITTER: Day AW 

PROVIDER: S-EPMC11888247 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature