Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health.

ABSTRACT: Major mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopathology. To this end, we introduce the Reproducible Brain Charts (RBC), an open data resource that integrates data from 5 large studies of brain development in youth from three continents (N=6,346; 45% Female). Confirmatory bifactor models were used to create harmonized psychiatric phenotypes that capture major dimensions of psychopathology. Following rigorous quality assurance, neuroimaging data were carefully curated and processed using consistent pipelines in a reproducible manner with DataLad, the Configurable Pipeline for the Analysis of Connectomes (C-PAC), and FreeSurfer. Initial

SUBMITTER: Shafiei G 

PROVIDER: S-EPMC11888297 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature