Beta-Hydroxybutyrate Inhibits Bronchial Smooth Muscle Contraction.

ABSTRACT: Asthma is a chronic respiratory condition characterized by airway inflammation, remodeling, and hyperresponsiveness to triggers causing airway constriction. Bronchial smooth muscle plays a critical role by narrowing airways, leading to obstruction and breathing difficulties, often exacerbated by mast cell infiltration and histamine release. Whereas current treatments, including bronchodilators, corticosteroids, and biologics provide effective management for most patients, alternative therapies are needed for difficult-to-treat asthma. Recent research highlights the potential of therapeutic ketosis, achieved through dietary interventions or supplementation with exogenous ketones, to reduce airway hyperresponsiveness and inflammation. Ketone bodies, known for providing energy during carbohyd

SUBMITTER: Fastiggi VA 

PROVIDER: S-EPMC11888348 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature