Open-Source DNA-Encoded Library informatics Package for Design, Decoding, and Analysis: DELi.

ABSTRACT: DNA-encoded library (DEL) technology has become a powerful tool in modern drug discovery. Fully harnessing its potential requires the use of extensive computational methodologies, which are often available only through proprietary software. This restricts accessibility for small teams lacking robust informatics support, hindering the growth of the technology. Here, we present DELi, an open-source DEL informatics platform designed for library design, NGS decoding and calling, and enrichment analysis. DELi supports a simple and easy to understand configuration setup to present a straightforward user interface. To showcase its capabilities, we used DELi to design an in-house custom, benzimidazole-based DEL (UNC DEL006), and performed proof-of-concept selection experiments against Bromodomain-

SUBMITTER: Wellnitz J 

PROVIDER: S-EPMC11888370 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature