Repulsive interactions instruct synaptic partner matching in an olfactory circuit.

ABSTRACT: Neurons exhibit extraordinary precision in selecting synaptic partners. Although cell-surface proteins (CSPs) mediating attractive interactions between developing axons and dendrites have been shown to instruct synaptic partner matching^1,2, the degree to which repulsive interactions play a role is less clear. Here, using a genetic screen guided by single-cell transcriptomes^3,4, we identified three CSP pairs-Toll2-Ptp10D, Fili-Kek1, and Hbs/Sns-Kirre-in mediating repulsive interactions between non-partner olfactory receptor neuron (ORN) axons and projection neuron (PN) dendrites in the developing Drosophila olfactory circuit. Each CSP pair exhibits inverse expression patterns in the select ORN-PN partners. Loss of each CSP in ORNs led to similar synaptic partner

SUBMITTER: Li Z 

PROVIDER: S-EPMC11888401 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature