Predicting the Regenerative Potential of Retinal Ganglion Cells Based on Developmental Growth Trajectories.

ABSTRACT: Retinal ganglion cells in the mammalian central nervous system fail to regenerate following injury, with the capacity to survive and regrow varying by cell type. This variability may be linked to differences in developmental programs that overlap with the genetic pathways that mediate regeneration. To explore this correlation, we compared the structural changes in mouse retinal ganglion cells during development with those occurring after axonal injury. The dendritic trees of over 1,000 ganglion cells were reconstructed at different developmental stages, revealing that each cell type follows a distinct timeline. ON-sustained (sONα) cells reach maturity by P14, whereas ON-transient (tONα) cells achieve their maximum dendritic size by P10. Modeling of the dendritic changes indicate that while

SUBMITTER: Santos JR 

PROVIDER: S-EPMC11888416 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature