Sphingolipid metabolism drives mitochondria remodeling during aging and oxidative stress.

ABSTRACT: One of the hallmarks of aging is a decline in the function of mitochondria, which is often accompanied by altered morphology and dynamics. In some cases, these changes may reflect macromolecular damage to mitochondria that occurs with aging and stress, while in other cases they may be part of a programmed, adaptive response. In this study, we report that mitochondria undergo dramatic morphological changes in chronologically aged yeast cells. These changes are characterized by a large, rounded morphology, decreased co-localization of outer membrane and matrix markers, and decreased mitochondrial membrane potential. Notably, these transitions are prevented by pharmacological or genetic interventions that perturb sphingolipid biosynthesis, indicating that sphingolipids are required for these

SUBMITTER: Ebert AC 

PROVIDER: S-EPMC11888424 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature