Shapley Fields Reveal Chemotopic Organization in the Mouse Olfactory Bulb Across Diverse Chemical Feature Sets.

ABSTRACT: Representations of chemical features in the neural activity of the olfactory bulb (OB) are not well-understood, unlike the neural code for stimuli of the other sensory modalities. This is because the space of olfactory stimuli lacks a natural coordinate system, and this significantly complicates characterizing neural receptive fields (tuning curves), analogous to those in the other sensory modalities. The degree to which olfactory tuning is spatially organized across the OB, often referred to as chemotopy, is also not well-understood. To advance our understanding of these aspects of olfactory coding, we introduce an interpretable method of Shapley fields, as an olfactory analog of retinotopic receptive fields. Shapley fields are spatial distributions of chemical feature importance for the

SUBMITTER: Milicevic N 

PROVIDER: S-EPMC11888437 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature