Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system.

ABSTRACT: Bacterial cells live under the constant existential threats imposed by other bacteria and viruses. Their mechanisms for contending with these threats are well documented; however, the regulation of these diverse defense elements remains poorly understood. Here we show that bacteria can mount a genome-wide, coordinated, and highly effective immune response against bacterial and viral threats using a single regulatory pathway. Bioinformatic analyses revealed that Pseudomonas species broadly possess a specialized form of the Gac/Rsm regulatory pathway (GRP), which our prior work in Pseudomonas aeruginosa implicated in activating interbacterial antagonism defense mechanisms in response to neighbor cell death. Proteomic studies comparing GRP-activated and -inactivated strains deri

SUBMITTER: Brinkley DM 

PROVIDER: S-EPMC11888443 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature