Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development.

ABSTRACT: During the first cell fate decision in mammalian embryos the inner cell mass cells, which will give rise to the embryo proper and other extraembryonic tissues, segregate from the trophectoderm cells, the precursors of the placenta. Cell fate segregation proceeds in a gradual manner encompassing two rounds of cell division, as well as cell positional and morphological changes. While it is known that the activity of the Hippo signaling pathway and the subcellular localization of its downstream effector YAP dictate lineage specific gene expression, the response of YAP to these dynamic cellular changes remains incompletely understood. Here we address these questions by quantitative live imaging of endogenously tagged YAP while simultaneously monitoring geometric cellular features and cell cycl

SUBMITTER: Chalifoux M 

PROVIDER: S-EPMC11888467 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature