Quantitative T1 mapping indicates elevated white matter myelin in children with RASopathies.

ABSTRACT:

Background

Evidence suggests pathological roles of myelination in neurodevelopmental disorders, but our understanding is limited. We investigated quantitative T1 mapping (QT1) as a clinically feasible tool for measuring myelination in children with neurodevelopmental disorders of the RAS-MAPK signaling pathway (RASopathies).

Methods

We collected QT1, diffusion-weighted, and structural MRI scans from 72 children (49 RASopathies, 23 typical developing (TD)). QT1 measures of myelin content included the macromolecular tissue volume (MTV) in white matter and R1 (1/T1 relaxation) of the cortex. For white matter, we assessed between-groups differences across 39 tracts. For cortical R1, we used principal components analysis to reduce dimensionality and capture myelination patterns a

SUBMITTER: Plank JR 

PROVIDER: S-EPMC11888482 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature