Kinetics of vibriocidal antibody responses among cholera patients in Goma, the Democratic Republic of Congo.

ABSTRACT: Cholera is a diarrheal disease that continues to burden vulnerable populations globally, primarily due to lack of clean water, optimal sanitation and adequate health infrastructure. Understanding the kinetics of antibody responses elicited by toxigenic Vibrio cholerae infection can inform the Sero-epidemiological estimation of disease burden and impact of vaccination efforts. While antibody kinetics have been well-described in South Asia, such studies based in Africa are lacking, despite the ongoing prevalence of cholera in that region. We enrolled stool culture-positive cholera patients admitted to cholera treatment centers in Goma, Democratic Republic of Congo (DRC) between August 2020 and October 2023. Blood samples were collected upon enrollment and during follow-up home visits.

SUBMITTER: Davis KL 

PROVIDER: S-EPMC11888488 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature