Early White Matter Microstructure Alterations in Infants with Down Syndrome.

ABSTRACT:

Importance

Down syndrome, resulting from trisomy 21, is the most prevalent chromosomal disorder and a leading cause of intellectual disability. Despite its significant impact on brain development, research on the white matter microstructure in infants with Down syndrome remains limited.

Objective

To investigate early white matter microstructure in infants with Down syndrome using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI).

Design

Infants were recruited and scanned between March 2019 and May 2024 as participants in prospective studies conducted by the Infant Brain Imaging Study (IBIS) Network. Data were analyzed in October 2024.

Setting

Data collection occurred at five research centers in Minnesota, Missouri, No

SUBMITTER: Azrak O 

PROVIDER: S-EPMC11888504 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature