Towards Scalable Biomarker Discovery in Posttraumatic Stress Disorder: Triangulating Genomic and Phenotypic Evidence from a Health System Biobank.

ABSTRACT:

Importance

Biomarkers can potentially improve the diagnosis, monitoring, and treatment of posttraumatic stress disorder (PTSD). However, PTSD biomarkers that are scalable and easily integrated into real-world clinical settings have not been identified.

Objective

To triangulate phenotypic and genomic evidence from a health system biobank with a goal of identifying scalable and clinically relevant biomarkers for PTSD.

Design setting and participants

The analysis was conducted between June to November 2024 using genomic samples and laboratory test results recorded in the Mass General Brigham (MGB) Health System. The analysis included 23,743 European ancestry participants from the nested MGB Biobank study.

Exposures

The first exposure was polygenic risk score (PRS)

SUBMITTER: Lee YH 

PROVIDER: S-EPMC11888531 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature