Early Activation of Lung CD8⁺ T Cells After Immunization with Live <i>Plasmodium berghei</i> Malaria Sporozoites.

ABSTRACT:

Background

Two novel malaria vaccines, RTS,S and R21, mark a significant step forward in malaria research, but eradication demands vaccines with higher efficacy. Recent trials using late-arresting genetically attenuated parasites (LA-GAP) highlight their effectiveness as next-generation vaccines, likely through CD8⁺ T-cell activation targeting late liver-stage parasites. However, the distribution of LA-GAP-activated T cells in different organs that culminate towards high-level protection in the liver remains unclear.

Methods

This study aimed to map immune responses in the livers and lungs of mice immunized with LA-GAP, shedding light on the role of different organs in priming T-cell responses towards immunity.

Results

Particularly in the lungs we found an i

SUBMITTER: van Schuijlenburg R 

PROVIDER: S-EPMC11888604 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature