Multiplexed fiber meta-tip-based circular polarimetry for label-free pathological analysis of ischemic stroke.

ABSTRACT:

Significance

We present an optical technology for a full-process label-free method for brain slice screening. This proposed multiplexed circular polarimetric method has the advantages of simple operation and high accuracy which may provide easily accessible evidence for the future diagnosis of related diseases.

Aim

One of its missions is to provide a quantifiable, reproducible analysis methodology that can replace or supplement traditional qualitative, subjective pathological analysis.

Approach

A label-free, sensitive, and rapid circular polarimetric method based on a multiplexed optical fiber meta-tip is proposed for the digital pathology of ischemic stroke. Polarization information of forward-scattered light is used to identify pathological variations of axon distri

SUBMITTER: Luan W 

PROVIDER: S-EPMC11888776 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature