Clinical, Genomic, and Neurophysiological Correlates of Lifetime Suicide Attempts among Individuals with an Alcohol Use Disorder.

ABSTRACT:

Introduction

Research has identified multiple risk factors associated with suicide attempt (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder (AUD), despite their disproportionately higher rates of SA.

Methods

We examined lifetime SA in 4,068 individuals with an AUD from the Collaborative Study on the Genetics of Alcoholism (23% lifetime SA; 53% female; mean age: 38). We explored risk for lifetime SA across other clinical conditions ascertained from a clinical interview, polygenic scores for comorbid psychiatric problems, and neurocognitive functioning.

Results

Participants with an AUD who attempted suicide had greater rates of trauma exposure, major depressive disorder, post-traumatic stress di

SUBMITTER: Barr PB 

PROVIDER: S-EPMC11888779 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature