COVID-19 booster doses reduce sex disparities in antibody responses among nursing home residents.

ABSTRACT:

Background

Data suggest that antibody responses following COVID-19 vaccines are a correlate of protection. Some studies, including the clinical trials of COVID-19 mRNA vaccines, did not stratify and evaluate whether antibody responses to COVID-19 vaccines differed between the sexes or with aging. This gap in research is particularly relevant for older populations such as nursing home residents (NHR). We hypothesized that sex differences in vaccine-induced antibody responses may intersect with age and be diminished among older adults residing in nursing homes.

Methods

We analyzed serum samples from 638 NHRs collected serially after the primary two-dose series and three subsequent booster doses of mRNA SARS-CoV-2 vaccinations. We analyzed anti-Spike IgG and neutralizing antibo

SUBMITTER: Oyebanji OA 

PROVIDER: S-EPMC11889018 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature