Periostin and rheumatic diseases: early insights from a systematic review and meta-analysis.

ABSTRACT: Periostin regulates angiogenesis, inflammation, and fibrosis, key processes in the pathophysiology of rheumatic diseases (RDs). However, its association with RDs has not been assessed. We conducted a systematic review and meta-analysis of studies reporting circulating periostin in RD patients and healthy controls. We searched electronic databases from inception to 30 November 2024 for relevant articles and assessed the risk of bias and the certainty of evidence using the JBI critical appraisal checklist and GRADE, respectively. In 12 eligible studies, there was a non-significant trend towards higher periostin concentrations in RD patients (standard mean difference, SMD = 0.46, 95% CI -0.07 to 0.98, p = 0.089; I² = 94.2%, p < 0.001). The results were stable in sensitivity analysi

SUBMITTER: Mangoni AA 

PROVIDER: S-EPMC11889030 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature