Causal associations between Sarcopenia-related traits and obstructive sleep apnea: a mendelian randomization study.

ABSTRACT:

Background

Evidence for a causal relationship between sarcopenia and obstructive sleep apnea (OSA) is scarce. This study aimed to investigate the causal association between sarcopenia-related traits and OSA utilizing Mendelian randomization (MR) analyses.

Methods

MR analyses were conducted using genetic instruments for sarcopenia-related traits, including hand grip strength, muscle mass, fat mass, water mass, and physical performance. Data from large-scale genome-wide association studies (GWAS) were utilized to identify genetic variants associated with these traits. Causal associations with OSA were assessed using various MR methods, including the inverse variance-weighted (IVW) method, MR-Egger, and weighted median approaches. Pleiotropy and heterogeneity were evaluated thr

SUBMITTER: Sun H 

PROVIDER: S-EPMC11889072 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature