Spatiotemporally resolved transcriptomics reveals the cellular dynamics of human retinal development.

ABSTRACT: The morphogenesis and cellular interactions in developing retina are incompletely characterized. The full understanding needs a precise mapping of the gene expression with a single-cell spatial resolution. Here, we present a spatial transcriptomic (ST) resource for the developing human retina at six developmental stages. Combining the spatial and single-cell transcriptomic data enables characterization of the cell-type-specific expression profiles at distinct anatomical regions at each developmental stage, highlighting the spatiotemporal dynamics of cellular composition during retinal development. All the ST spots are catalogued into consensus spatial domains, which are further associated to their specific expression signatures and biological functions associated with neuron and eye develo

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11889126 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature