Effects of reduced extracellular sodium on proliferation and invasive activity of renal cell carcinoma cell lines.

ABSTRACT: Hyponatremia is the most common electrolyte disorder in cancer patients and is associated with a worse outcome. This finding has also been reported in patients with metastatic renal cell carcinoma (mRCC). We have previously demonstrated that low extracellular sodium concentrations ([Na⁺]) increase cell proliferation and invasion in several human cancer cell lines. The aim of the present study was to evaluate in vitro the effects of mild [Na⁺] alterations on two mRCC cell lines, ACHN and Caki-1. After growth in reduced extracellular [Na⁺], we observed that even mild reductions of [Na⁺] significantly enhanced different key cancer cell features, including proliferation, invasion and migration. Furthermore, we observed a reduction in reactive oxygen

SUBMITTER: Naldi L 

PROVIDER: S-EPMC11889168 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature