A simplified in vitro disease-mimicking culture system can determine the angiogenic effect of medicines on vascular diseases.

ABSTRACT: Many patients undergoing clinical regenerative treatments experience severe conditions arising from endothelial disruption. In chronic cardiac and perivascular diseases, deficiencies in vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), and heparin, which are essential for maintaining and activating endothelial cells, can lead to angiogenic dysregulation. Endothelial disruption caused by ischemic hypoxia and a deficiency in these factors is associated with many vascular diseases. However, their pathogenic processes remain unclear at the cellular level. Therefore, the present study aimed to develop a culture system that mimics the disease environment to test the effectiveness of drug candidates in restoring damaged blood vessels in chronic vascular diseases, includ

SUBMITTER: Moon S 

PROVIDER: S-EPMC11889311 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature