Arrival time mapping with ¹⁵O-gas PET for cerebrovascular steno-occlusive diseases: a comparative study with CT perfusion.

ABSTRACT:

Background

Positron emission tomography (PET) with ¹⁵O-gas for quantifying cerebral blood flow (CBF) and oxygen metabolism is the gold standard for assessing hemodynamics in ischemic cerebrovascular disease. However, conventional ¹⁵O-gas PET methods do not provide information on regional arrival timing, a hemodynamic parameter typically measured using computed tomography (CT) perfusion with contrast media. This study demonstrated that ¹⁵O-gas PET with a state-of-the-art clinical PET scanner and optimized analysis can generate arrival time maps. In this retrospective study of ten patients with unilateral stenosis or occlusion of the major arteries, we compared PET-derived arrival time maps with CT perfusion Tmax maps.

Results

In PET with short

SUBMITTER: Ibaraki M 

PROVIDER: S-EPMC11889313 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature