Intratumoral and peritumoral ultrasound-based radiomics for preoperative prediction of HER2-low breast cancer: a multicenter retrospective study.

ABSTRACT:

Objectives

Recent advances in human epidermal growth factor receptor 2 (HER2)-targeted therapies have opened up new therapeutic options for HER2-low cancers. This study aimed to establish an ultrasound-based radiomics model to identify three different HER2 states noninvasively.

Methods

Between May 2018 and December 2023, a total of 1257 invasive breast cancer patients were enrolled from three hospitals. The HER2 status was divided into three classes: positive, low, and zero. Four peritumoral regions of interest (ROI) were auto-generated by dilating the manually segmented intratumoral ROI to thicknesses of 5 mm, 10 mm, 15 mm, and 20 mm. After image preprocessing, 4720 radiomics features were extracted from each image of every patient. The least absolute shrinkage and selectio

SUBMITTER: Luo S 

PROVIDER: S-EPMC11889314 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature