Erythritol, Erythronate, and Cardiovascular Outcomes in Older Adults in the ARIC Study.

ABSTRACT:

Background

Circulating erythritol, an endogenously produced metabolite and an artificial sweetener, is associated with cardiovascular outcomes.

Objectives

The authors assessed associations of erythritol and its downstream metabolite, erythronate, with cardiovascular risk factors and events in older adults in the ARIC (Atherosclerosis Risk In Communities) study (visit 5, 2011-2013).

Methods

We included 4,006 participants without prevalent cardiovascular disease and with metabolomic profiling. Erythritol and erythronate were measured by mass spectrometry. We analyzed associations of log-transformed erythritol and erythronate with cardiovascular risk factors and events using Cox proportional hazard models.

Results

Participants in the highest tertiles of erythritol

SUBMITTER: Abushamat LA 

PROVIDER: S-EPMC11889355 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature