The molecular mechanism of ginsenoside Rh2 and its octyl ester derivative on anti-angiogenesis in cancer treatment: The battle between PI3K and ROS.

ABSTRACT:

Background

The cancer treatments that target tumor associated angiogenesis (TAA) induced by vascular endothelial growth factor A (VEGFA) have become valued. Ginsenoside Rh2 has been proved to inhibit TAA through VEGFA. However, the underlying mechanisms remain unclear. Moreover, the octyl ester derivative of Rh2 (Rh2-O) exhibited better inhibitory effects than Rh2 on liver cancer in our previous researches, which indicated that Rh2-O might also exert inhibitory effects on TAA.

Purpose

To explore the inhibitory effects of Rh2 and Rh2-O on TAA and to investigate the underlying mechanisms.

Method

The inhibitory effects of Rh2 and Rh2-O on TAA were evaluated by conditioned medium, co-culture, and tumor-bearing mice. The network pharmacology was used to explore the possibl

SUBMITTER: Hu QR 

PROVIDER: S-EPMC11889380 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature