Unlocking the Potential of Freeze-Dried Broccoli Powder: A Novel Approach to Enhancing Cognitive Resilience in Temporal Lobe Epilepsy.

ABSTRACT: Cognitive impairment frequently accompanies temporal lobe epilepsy (TLE), which is linked to oxidative stress. Freeze-dried broccoli powder (BROC) exhibits diverse biological activities, particularly its antioxidant properties. Our study explored the effects of BROC on post-epileptic cognitive function. Male mice with lithium-pilocarpine-induced epilepsy were randomly divided into three groups: control group, model group (basal diet), and broccoli intervention group (basal diet supplemented with 4% BROC). Following 60 days of intervention, cognitive function was evaluated using IntelliCage Learning Tests, Novel Object Recognition, and Shuttle Box Tests. The hippocampal levels of malondialdehyde (MDA) and antioxidant enzyme activities were measured, and the protein expression levels of HO-1

SUBMITTER: Gong Y 

PROVIDER: S-EPMC11889413 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature