Protocol for isolation and expansion of natural killer cells from human peripheral blood scalable for clinical applications.

ABSTRACT: Natural killer (NK) cells have emerged as promising candidates for novel immunotherapy strategies against various malignancies. Their unique ability to recognize and eliminate tumour cells without prior sensitization, coupled with the secretion of pro-inflammatory cytokines such as interferon-gamma and tumour necrosis factor, position them as promising agents in cancer therapy. Adoptive NK cell transfer has shown particular promise in haematological malignancies, where NK cell infusions could achieve remission in a high proportion of patients. Moreover, the possibility to engineer NK cells to express chimeric antigen receptors can further enhance their efficacy, thereby broadening their applicability to include solid tumours. Ongoing research is crucial to optimize NK cell therapies and en

SUBMITTER: Kundu S 

PROVIDER: S-EPMC11889455 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature